| http://purl.uniprot.org/citations/19249753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19249753 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation. However, the relative importance and contribution of each pathway towards T cell-mediated immunity is still not clear. To address this issue, we compared T cell responses of WT, CD28 knockout (KO), B7-H2 KO, and CD28-B7-H2 double KO (DKO) mice in a model of delayed-type hypersensitivity (DTH). While CD28 KO mice have partially compromised DTH response, DKO mice exhibited greatly diminished response, suggesting that the ICOS/B7-H2 pathway could partially compensate for the costimulation of DTH. Surprisingly, B7-H2 KO mice had comparable DTH response as WT mice, indicating that the ICOS/B7-H2 pathway is secondary to the CD28/B7 pathway in costimulating DTH. Interestingly, prolonging the period of sensitization could overcome the compromised DTH response in CD28 KO but not DKO mice, revealing a novel form of functional redundancy of ICOS/B7-H2 costimulation that is dependent on time to take effect. Taken together, our data reveal a functional hierarchy of the CD28/B7 and ICOS/B7-H2 pathways and delineated their relative contributions to the elicitation of a DTH response."xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2009.01.009"xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://purl.uniprot.org/core/author | "Wong S.C."xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://purl.uniprot.org/core/author | "Lam K.P."xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://purl.uniprot.org/core/author | "Tan A.H."xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19249753 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://purl.uniprot.org/core/pages | "64-71"xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://purl.uniprot.org/core/title | "Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity."xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://purl.uniprot.org/core/volume | "256"xsd:string |
| http://purl.uniprot.org/citations/19249753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19249753 |
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| http://purl.uniprot.org/uniprot/#_A0A1W2P6Q2-mappedCitation-19249753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19249753 |
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| http://purl.uniprot.org/uniprot/#_Q544C7-mappedCitation-19249753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19249753 |