| http://purl.uniprot.org/citations/1926167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1926167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1926167 | http://www.w3.org/2000/01/rdf-schema#comment | "Toxins T1IV (TsTX-III) and T2IV have been purified to homogeneity from Tityus serrulatus scorpion venom and further characterized. Their amino acid composition and SDS-PAGE reveal an approximate mol. wt of 7000. Their intracisternal LD50 (micrograms/kg) in mice were 12.9 +/- 1.6 and 3.0 +/-0.5, while their N-terminal amino acid sequences were K-E-G-Y-A-M-D-H-E-G-C-K-F-S- and K-E-G-Y-L-M-D-H-E-G-C-K-L-S-C-F-I-R-P-S-G-Y-C-G-R-E-, respectively. This sequence of T2IV, its amino acid composition and its chromatographic and electrophoretic behaviour identify it as toxin gamma (TsTX-I), which is the major toxin from this venom. TsTX-III (13 to 102 micrograms/kg) produced a long lasting enhancement of the hypertensive effect of noradrenaline and a slight decrease of the hypotensive effect of acetylcholine, while T2IV (115 micrograms/kg) induced a prolonged hypotensive effect on the anesthetized rat. On the isolated guinea-pig vas deferens, TsTX-III (2.1 and 3.0 micrograms/ml) produced a horizontal shift of the dose-response curve for noradrenaline to the left with no change of the maximal response. At a concentration of 1.43 microM, it induced a prolongation of the duration of the B component of the compound action potential. This prolongation was strongly reduced after addition of tetrodotoxin."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.org/dc/terms/identifier | "doi:10.1016/0041-0101(91)90058-y"xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.org/dc/terms/identifier | "doi:10.1016/0041-0101(91)90058-y"xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Giglio J.R."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Giglio J.R."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Arantes E.C."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Arantes E.C."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Sampaio S.V."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Sampaio S.V."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Prado W.A."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Prado W.A."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Riccioppo Neto F."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/author | "Riccioppo Neto F."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/pages | "663-672"xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/pages | "663-672"xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/title | "Further characterization of toxins T1IV (TsTX-III) and T2IV from Tityus serrulatus scorpion venom."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/title | "Further characterization of toxins T1IV (TsTX-III) and T2IV from Tityus serrulatus scorpion venom."xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/1926167 | http://purl.uniprot.org/core/volume | "29"xsd:string |