| http://purl.uniprot.org/citations/19261853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19261853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19261853 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to Parkinson's disease (PD) and memory and is selectively expressed in neurons at high levels. Its expression pattern suggests a function distinct from that of its widely expressed homolog UCH-L3. We report here that, in contrast to UCH-L3, UCH-L1 exists in a membrane-associated form (UCH-L1(M)) in addition to the commonly studied soluble form. C-terminal farnesylation promotes the association of UCH-L1 with cellular membranes, including the endoplasmic reticulum. The amount of UCH-L1(M) in transfected cells is shown to correlate with the intracellular level of alpha-synuclein, a protein whose accumulation is associated with neurotoxicity and the development of PD. Reduction of UCH-L1(M) in cell culture models of alpha-synuclein toxicity by treatment with a farnesyltransferase inhibitor (FTI-277) reduces alpha-synuclein levels and increases cell viability. Proteasome function is not affected by UCH-L1(M), suggesting that it may negatively regulate the lysosomal degradation of alpha-synuclein. Therefore, inhibition of UCH-L1 farnesylation may be a therapeutic strategy for slowing the progression of PD and related synucleinopathies."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0806474106"xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0806474106"xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Cookson M.R."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Cookson M.R."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Lansbury P.T. Jr."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Lansbury P.T. Jr."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Logan T."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Logan T."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Fredenburg R.A."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Fredenburg R.A."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Grammatopoulos T.N."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Grammatopoulos T.N."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Meray R.K."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/author | "Meray R.K."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19261853 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |