| http://purl.uniprot.org/citations/19262071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19262071 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo compare plasma concentrations of acetylsalicylic acid (ASA) and its metabolites between genetic polymorphisms in the gene encoding for UDP-glucuronosyltransferase 1A6 (UGT1A6), an enzyme involved in ASA metabolism.MethodsFive UGT1A6*1 and 4 UGT1A6*2 homozygote females were given 320 mg ASA once daily for 8 days. During the first and last day of treatment, several blood samples were taken over a 10-hour time period and analyzed for plasma levels of ASA and its main metabolites salicylic acid (SA) and salicyluric acid (SUA), using a validated HPLC method. The pharmacokinetic data were assessed with the Time Constant Approach and both genotypes were compared using the Mann-Whitney U test.ResultsASA and SUA showed similar pharmacokinetic parameters in the two UGT1A6 genotypes. However, pharmacokinetic parameters for SA differed significantly: the mean area under the pharmacokinetic curve for the UGT1A6*1 and UGT1A6*2 homozygotes was 136 and 94 microg/ml.h (p = 0.04), and median C(max) was 23 and 17 microg/ml (p = 0.01), respectively.ConclusionIn females receiving ASA, the presence of the UGT1A6*2 compared to the UGT1A6*1 homozygote genotype is associated with lower plasma levels of SA, indicating faster pharmacokinetics."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.org/dc/terms/identifier | "doi:10.1159/000205824"xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "Smits P."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "Barthelemy C."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "Peters W.H."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "Janssen M.J."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "Jansen J.B."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "Laheij R.J."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "van Oijen M.G."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "Joiris E."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/author | "Odou P."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/name | "Pharmacology"xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/pages | "237-242"xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/title | "Effect of genetic polymorphisms in UDP-glucuronosyltransferase 1A6 (UGT1A6) on acetylsalicylic acid metabolism in healthy female volunteers."xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/19262071 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19262071 |
| http://purl.uniprot.org/citations/19262071 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19262071 |
| http://purl.uniprot.org/uniprot/#_P19224-mappedCitation-19262071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262071 |
| http://purl.uniprot.org/uniprot/#_P22309-mappedCitation-19262071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262071 |
| http://purl.uniprot.org/uniprot/#_P22310-mappedCitation-19262071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262071 |
| http://purl.uniprot.org/uniprot/#_P35503-mappedCitation-19262071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262071 |
| http://purl.uniprot.org/uniprot/#_P35504-mappedCitation-19262071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262071 |
| http://purl.uniprot.org/uniprot/#_Q5DSZ8-mappedCitation-19262071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262071 |