| http://purl.uniprot.org/citations/19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19262578 | http://www.w3.org/2000/01/rdf-schema#comment | "The CDKN1A gene encoding a cell cycle inhibitor, p21(WAF1/CIP1), is located in the systemic lupus erythematosus (SLE) susceptibility locus on chromosome 6p21.2. Decreased cellular levels of p21 are associated with SLE. Here, we examine four single-nucleotide polymorphisms (SNPs) within the promoter and two in the first intron of CDKN1A for association with SLE susceptibility. A comparison of 742 Korean SLE patients with 1017 controls disclosed that one SNP (rs762624 C>A at position -899), located at a putative Myb-binding site in the promoter, was associated with SLE susceptibility (P=0.00047). This association was independent of the SLE-association signal of HLA-DRB1 on 6p21.3, as it was significant after adjustment for SLE-risk DRB1 alleles (P=0.0012). The same SNP was associated with lupus nephritis (P=0.000014). The risk allele-carrying promoter sequence displayed approximately 15% lower activity than the non-risk sequence upon fusion to the luciferase gene (P=0.025). Endogenous CDKN1A mRNA levels measured in Epstein-Barr virus-transformed B cells established from 16 control subjects were linearly correlated with a decreasing copy number of the risk allele (P=0.024). Accordingly, we conclude that the minor allele A at -899 of CDKN1A is associated with increased susceptibility to SLE and lupus nephritis, and decreased cellular levels of p21."xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2009.5"xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/author | "Kang C."xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/author | "Sung Y.K."xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/author | "Bae S.C."xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/author | "Kang C.P."xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/author | "Choi C.B."xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/pages | "482-486"xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/title | "A regulatory SNP at position -899 in CDKN1A is associated with systemic lupus erythematosus and lupus nephritis."xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/19262578 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19262578 |
| http://purl.uniprot.org/citations/19262578 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-19262578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19262578 |