| http://purl.uniprot.org/citations/19264960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19264960 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease is a neurodegenerative disorder characterized by the accumulation of amyloid plaques in the brain. This amyloid primarily contains amyloid-beta (Abeta), a 39-to 43-aa peptide derived from the proteolytic cleavage of the endogenous amyloid precursor protein. The 42-residue-length Abeta peptide (Abeta(1-42)), the most abundant Abeta peptide found in plaques, has a much greater propensity to self-aggregate into fibrils than the other peptides and is believed to be more pathogenic. Synthetic human Abeta(1-42) peptides self-aggregate into stable but poorly-ordered helical filaments. We determined their structure to approximately 10-A resolution by using cryoEM and the iterative real-space reconstruction method. This structure reveals 2 protofilaments winding around a hollow core. Previous hairpin-like NMR models for Abeta(17-42) fit well in the cryoEM density map and reveal that the juxtaposed protofilaments are joined via the N terminus of the peptide from 1 protofilament connecting to the loop region of the peptide in the opposite protofilament. This model of mature Abeta(1-42) fibrils is markedly different from previous cryoEM models of Abeta(1-40) fibrils. In our model, the C terminus of Abeta forms the inside wall of the hollow core, which is supported by partial proteolysis analysis."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0901085106"xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/author | "Chiu W."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/author | "Lee J.M."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/author | "Schmid M.F."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/author | "Frieden C."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/author | "Ludtke S.J."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/author | "Khant H."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/pages | "4653-4658"xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/title | "Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM."xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19264960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19264960 |
| http://purl.uniprot.org/citations/19264960 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19264960 |
| http://purl.uniprot.org/uniprot/P05067#attribution-1AAE993BE9D99CDE0B11EFB8E637B986 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19264960 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRG2-mappedCitation-19264960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19264960 |
| http://purl.uniprot.org/uniprot/#_A0A140VJC8-mappedCitation-19264960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19264960 |
| http://purl.uniprot.org/uniprot/#_A0A218KGR2-mappedCitation-19264960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19264960 |
| http://purl.uniprot.org/uniprot/#_A0A8F9R5D5-mappedCitation-19264960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19264960 |
| http://purl.uniprot.org/uniprot/#_B4DGD0-mappedCitation-19264960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19264960 |
| http://purl.uniprot.org/uniprot/#_B4DMD5-mappedCitation-19264960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19264960 |