| http://purl.uniprot.org/citations/19265110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19265110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19265110 | http://www.w3.org/2000/01/rdf-schema#comment | "PTPN22 is a gene encoding the protein tyrosine phosphatase Lyp. A missense mutation changing residue 1858 from cytosine to thymidine (1858C/T) is associated with multiple autoimmune disorders. Studies have demonstrated that Lyp has an inhibitory effect on TCR signaling; however, the presence of autoantibodies in all of the diseases associated with the 1858T variant and recent evidence that Ca(2+) flux is altered in B cells of 1858T carriers indicate a role for Lyp in B cell signaling. In this study we show that B cell signal transduction is impaired in individuals who express the variant. This defect in signaling is characterized by a deficit in proliferation, a decrease in phosphorylation of key signaling proteins, and is reversed by inhibition of Lyp. These findings suggest that the PTPN22 1858T variant alters BCR signaling and implicate B cells in the mechanism by which the PTPN22 1858T variant contributes to autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0713370"xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0713370"xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Funk A."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Funk A."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Zhang Z.Y."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Zhang Z.Y."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Habib T."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Habib T."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Buckner J.H."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Buckner J.H."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Arechiga A.F."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/author | "Arechiga A.F."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/pages | "3343-3347"xsd:string |
| http://purl.uniprot.org/citations/19265110 | http://purl.uniprot.org/core/pages | "3343-3347"xsd:string |