| http://purl.uniprot.org/citations/19265111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19265111 | http://www.w3.org/2000/01/rdf-schema#comment | "Tolerogenic dendritic cells (DC) play an important role in maintaining peripheral T cell tolerance in steady-state conditions through induction of anergic, IL-10-producing T cells with suppressive properties. ICOS, an activation-induced member of the CD28 family on T cells, is involved in the induction of IL-10, which itself could contribute to induction of anergy and development of suppressive T cells. Therefore, we analyzed the functional role of ICOS in the differentiation process of human CD4(+) T cells upon their interaction with tolerogenic DC. We compared the functional properties of CD4(+) T cells from healthy volunteers and ICOS-deficient patients after stimulation with tolerogenic DC. We report that induction of T cell anergy and suppressive capacity is completely blocked after knockdown of ICOS expression in T cells as well as after blocking of ICOS-ICOS ligand interaction in DC/T cell cocultures. Moreover, CD4(+) T cells from ICOS-deficient patients were completely resistant to anergy induction and differentiation into suppressive T cells even after supplementation of IL-10. Furthermore, ICOS/ICOS ligand interaction stabilizes IL-10R expression on T cells and thus renders them sensitive to IL-10 effects. Taken together, these results indicate a crucial role for ICOS in the induction of peripheral tolerance maintained by tolerogenic DC mediated mostly via an IL-10-independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0802733"xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Horn J."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Grimbacher B."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Kroczek R.A."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Stoll S."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Knop J."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Huter E."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Jonuleit H."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Tuettenberg A."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/author | "Hubo M."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/pages | "3349-3356"xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/title | "The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19265111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19265111 |
| http://purl.uniprot.org/citations/19265111 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19265111 |
| http://purl.uniprot.org/uniprot/#_Q53QY6-mappedCitation-19265111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19265111 |
| http://purl.uniprot.org/uniprot/#_Q9Y6W8-mappedCitation-19265111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19265111 |
| http://purl.uniprot.org/uniprot/Q53QY6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19265111 |
| http://purl.uniprot.org/uniprot/Q9Y6W8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19265111 |