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| http://purl.uniprot.org/citations/19269369 | http://www.w3.org/2000/01/rdf-schema#comment | "TRIM-NHL proteins represent a large class of metazoan proteins implicated in development and disease. We demonstrate that a C. elegans TRIM-NHL protein, NHL-2, functions as a cofactor for the microRNA-induced silencing complex (miRISC) and thereby enhances the posttranscriptional repression of several genetically verified microRNA targets, including hbl-1 and let-60/Ras (by the let-7 family of microRNAs) and cog-1 (by the lsy-6 microRNA). NHL-2 is localized to cytoplasmic P-bodies and physically associates with the P-body protein CGH-1 and the core miRISC components ALG-1/2 and AIN-1. nhl-2 and cgh-1 mutations compromise the repression of microRNA targets in vivo but do not affect microRNA biogenesis, indicating a role for an NHL-2:CGH-1 complex in the effector phase of miRISC activity. We propose that the NHL-2:CGH-1 complex functions in association with mature miRISC to modulate the efficacy of microRNA:target interactions in response to physiological and developmental signals, thereby ensuring the robustness of genetic regulatory pathways regulated by microRNAs."xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.01.053"xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/author | "Ambros V."xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/author | "Blackwell T.K."xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/author | "Hammell C.M."xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/author | "Boag P.R."xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/author | "Lubin I."xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/pages | "926-938"xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/title | "nhl-2 Modulates microRNA activity in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19269369 | http://purl.uniprot.org/core/volume | "136"xsd:string |
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