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http://purl.uniprot.org/citations/19270442http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19270442http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

Engrailed-2 is a homeobox transcription factor that is expressed in mesencephalic dopaminergic neurons from development to adulthood and probably plays an important role in the survival of these neurons.

Methods

Here, we investigated six single-nucleotide polymorphisms (SNPs) in the promoter region (rs1345514) or transcribed part (rs3735653, rs6460013, rs1861972, rs2361689, and rs3808330) of the engrailed-2 gene, respectively, in 103 discordant pairs with young-onset Parkinson's disease (YOPD).

Results

The nominally significant p values in the single-marker and haplotype-based association analysis were suggestive of an association of SNP rs1345514 with YOPD.

Conclusion

Altogether, our data suggest the possibility that variations of the engrailed-2 gene are implicated in the development of YOPD, although our results with respect to SNP rs1345514 should be verified in an independent sample."xsd:string
http://purl.uniprot.org/citations/19270442http://purl.org/dc/terms/identifier"doi:10.1159/000207796"xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/author"Oertel W.H."xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/author"Strauch K."xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/author"Moller J.C."xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/author"Rissling I."xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/author"Hoft C."xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/name"Neurodegener Dis"xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/pages"102-105"xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/title"Haplotype analysis of the engrailed-2 gene in young-onset Parkinson's disease."xsd:string
http://purl.uniprot.org/citations/19270442http://purl.uniprot.org/core/volume"6"xsd:string
http://purl.uniprot.org/citations/19270442http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19270442
http://purl.uniprot.org/citations/19270442http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19270442
http://purl.uniprot.org/uniprot/#_P19622-mappedCitation-19270442http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19270442
http://purl.uniprot.org/uniprot/P19622http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19270442