| http://purl.uniprot.org/citations/19270716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19270716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19270716 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon (IFN)-induced signalling pathways have essential functions in innate immune responses. In response to type I IFNs, filamin B tethers RAC1 and a Jun N-terminal kinase (JNK)-specific mitogen-activated protein kinase (MAPK) module--MEKK1, MKK4 and JNK--and thereby promotes the activation of JNK and JNK-mediated apoptosis. Here, we show that type I IFNs induce the conjugation of filamin B by interferon-stimulated gene 15 (ISG15). ISGylation of filamin B led to the release of RAC1, MEKK1 and MKK4 from the scaffold protein and thus to the prevention of sequential activation of the JNK cascade. By contrast, blockade of filamin B ISGylation by substitution of Lys 2467 with arginine or by knockdown of ubiquitin-activating enzyme E1-like (UBEL1) prevented the release of the signalling molecules from filamin B, resulting in persistent promotion of JNK activation and JNK-mediated apoptosis. These results indicate that filamin B ISGylation acts as a negative feedback regulatory gate for the desensitization of type I IFN-induced JNK signalling."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2009.23"xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2009.23"xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Choi J.S."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Choi J.S."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Kim S.M."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Kim S.M."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Chung C.H."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Chung C.H."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Zhang D.E."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Zhang D.E."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Kim K.I."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Kim K.I."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Jeon Y.J."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Jeon Y.J."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Yu K.R."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Yu K.R."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Ka S.H."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Ka S.H."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Oh K.H."xsd:string |
| http://purl.uniprot.org/citations/19270716 | http://purl.uniprot.org/core/author | "Oh K.H."xsd:string |