| http://purl.uniprot.org/citations/19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19272180 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. Here, we show that ectopic expression of hTERT stimulates telomerase activity and prevents accelerated senescence in G6PD-deficient cells. Stable clones derived from hTERT-expressing normal and G6PD-deficient fibroblasts have normal karyotypes, and display no sign of senescence beyond 145 and 105 passages, respectively. Activation of telomerase, however, does not prevent telomere attrition in earlier-passage cells, but does stabilize telomere lengths at later passages. In addition, we provide evidence that ectopic expression of hTERT attenuates the increased sensitivity of G6PD-deficient fibroblasts to oxidant-induced senescence. These results suggest that ectopic expression of hTERT, in addition to acting in telomere length maintenance by activating telomerase, also functions in regulating senescence induction."xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.org/dc/terms/identifier | "doi:10.1186/1423-0127-16-18"xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/author | "Wang T.C."xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/author | "Ho H.Y."xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/author | "Cheng M.L."xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/author | "Wu Y.H."xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/author | "Chiu D.T."xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/name | "J Biomed Sci"xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/pages | "18"xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/title | "Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/19272180 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19272180 |
| http://purl.uniprot.org/citations/19272180 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19272180 |
| http://purl.uniprot.org/uniprot/#_Q0PHS1-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_Q0PHS2-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_Q0PHS3-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_Q0PHS4-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_Q0PHS5-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_Q0PHS6-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_A0A8G1M3Q3-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_A2IBT6-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_A7IZZ3-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |
| http://purl.uniprot.org/uniprot/#_A0A384NL00-mappedCitation-19272180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19272180 |