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| http://purl.uniprot.org/citations/19273270 | http://www.w3.org/2000/01/rdf-schema#comment | "The macro module is a globular protein domain of about 25 kDa that is evolutionarily conserved in organisms from viruses, bacteria, yeast to humans. It is generally part of proteins that have wide-ranging (and yet to be discovered) cellular functions. There are several examples of macro domains associated with modules showing homology to poly-ADP-ribosyl-polymerases. Many macro domains, including those of the human histone macroH2A1.1, bind NAD metabolites such as ADP-ribose, suggesting that macro domains may function in the recognition of this and related molecules. The presence of a metabolite-binding function in a repressive chromatin component opens new potential connections between chromosome structure, gene silencing and cellular metabolism. Current evidence suggests that macro domains also represent a novel tool for studying NAD metabolites and may be an attractive drug target for the treatment of diseases."xsd:string |
| http://purl.uniprot.org/citations/19273270 | http://purl.org/dc/terms/identifier | "doi:10.2741/3448"xsd:string |
| http://purl.uniprot.org/citations/19273270 | http://purl.uniprot.org/core/author | "Till S."xsd:string |
| http://purl.uniprot.org/citations/19273270 | http://purl.uniprot.org/core/author | "Ladurner A.G."xsd:string |
| http://purl.uniprot.org/citations/19273270 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19273270 | http://purl.uniprot.org/core/name | "Front Biosci (Landmark Ed)"xsd:string |
| http://purl.uniprot.org/citations/19273270 | http://purl.uniprot.org/core/pages | "3246-3258"xsd:string |
| http://purl.uniprot.org/citations/19273270 | http://purl.uniprot.org/core/title | "Sensing NAD metabolites through macro domains."xsd:string |
| http://purl.uniprot.org/citations/19273270 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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