| http://purl.uniprot.org/citations/19273609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19273609 | http://www.w3.org/2000/01/rdf-schema#comment | "Characterizing mechanisms regulating mammary cell growth and differentiation is vital, as they may contribute to breast carcinogenesis. Here, we examine a cross talk mechanism(s) downstream of prolactin (PRL), a primary differentiation hormone, and epidermal growth factor (EGF), an important proliferative factor, in mammary epithelial cell growth and differentiation. Our data indicate that EGF exerts inhibitory effects on PRL-induced cellular differentiation by interfering with Stat5a-mediated gene expression independent of the PRL-proximal signaling cascade. Additionally, our data show that PRL is a potent inhibitor of EGF-induced cell proliferation. We identify tyrosine phosphorylation of the growth factor receptor-bound protein 2 (Grb2) as a critical mechanism by which PRL antagonizes EGF-induced cell proliferation by attenuating the activation of the Ras/mitogen-activated protein kinase (MAPK) pathway. Together, our results define a novel negative cross-regulation between PRL and EGF involving the Jak2/Stat5a and Ras/MAPK pathways through tyrosine phosphorylation of Grb2."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00034-09"xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Feng Z."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Ali S."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Alvarez L."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Lebrun J.J."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Campiglio M."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Minoo P."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Cocolakis E."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Di Fulvio M."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Nie X.M."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Haines E."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Gomez-Cambronero J."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Resalatpanah N."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/author | "Ridha M."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/pages | "2505-2520"xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/title | "Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation."xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19273609 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19273609 |
| http://purl.uniprot.org/citations/19273609 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19273609 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDT8-mappedCitation-19273609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19273609 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JF92-mappedCitation-19273609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19273609 |