| http://purl.uniprot.org/citations/19279008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19279008 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of protein kinase C (PKC) by the phorbol ester (phorbol 12-myristate 13-acetate) induces ceramide formation through the salvage pathway involving, in part, acid beta-glucosidase 1 (GBA1), which cleaves glucosylceramide to ceramide. Here, we examine the role of the GBA1-ceramide pathway, in regulating a pro-inflammatory pathway initiated by PKC and leading to activation of p38 and induction of interleukin 6 (IL-6). Inhibition of ceramide formation by fumonisin B1 or down-regulation of PKCdelta potentiated PMA-induced activation of p38 in human breast cancer MCF-7 cells. Similarly, knockdown of GBA1 by small interfering RNAs or pharmacological inhibition of GBA1 promoted further activation of p38 after PMA treatment, implicating the GBA1-ceramide pathway in the termination of p38 activation. Knockdown of GBA1 also evoked the hyperproduction of IL-6 in response to 4beta phorbol 12-myristate 13-acetate. On the other hand, increasing cellular ceramide with cell-permeable ceramide treatment resulted in attenuation of the IL-6 response. Importantly, silencing the delta isoform of the p38 family significantly attenuated the hyperproduction of IL-6. Reciprocally, p38delta overexpression induced IL-6 biosynthesis. Thus, the GBA1-ceramide pathway is suggested to play an important role in terminating p38delta activation responsible for IL-6 biosynthesis. Furthermore, the p38delta isoform was identified as a novel and predominant target of ceramide signaling as well as a regulator of IL-6 biosynthesis."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m809500200"xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/author | "Grabowski G.A."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/author | "Hannun Y.A."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/author | "Obeid L.M."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/author | "Jenkins R.W."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/author | "Kitatani K."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/author | "Anelli V."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/author | "Sheldon K."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/pages | "12979-12988"xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/title | "Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid."xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19279008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19279008 |
| http://purl.uniprot.org/citations/19279008 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19279008 |
| http://purl.uniprot.org/uniprot/P17405#attribution-895912E3B4C053732DB06B7835B952BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19279008 |
| http://purl.uniprot.org/uniprot/P04062#attribution-4319B1FE23EF7E4069E87D7DC7C7FF62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19279008 |
| http://purl.uniprot.org/uniprot/P04062#attribution-5D25E80F79219CD2036E411B068EE62F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19279008 |
| http://purl.uniprot.org/uniprot/P04062#attribution-895912E3B4C053732DB06B7835B952BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19279008 |
| http://purl.uniprot.org/uniprot/Q05655#attribution-4319B1FE23EF7E4069E87D7DC7C7FF62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19279008 |
| http://purl.uniprot.org/uniprot/Q05655#attribution-895912E3B4C053732DB06B7835B952BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19279008 |
| http://purl.uniprot.org/uniprot/O15264#attribution-4319B1FE23EF7E4069E87D7DC7C7FF62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19279008 |