| http://purl.uniprot.org/citations/19279323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19279323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19279323 | http://www.w3.org/2000/01/rdf-schema#comment | "As a stress response, senescence is a dynamic process involving multiple effector mechanisms whose combination determines the phenotypic quality. Here we identify autophagy as a new effector mechanism of senescence. Autophagy is activated during senescence and its activation is correlated with negative feedback in the PI3K-mammalian target of rapamycin (mTOR) pathway. A subset of autophagy-related genes are up-regulated during senescence: Overexpression of one of those genes, ULK3, induces autophagy and senescence. Furthermore, inhibition of autophagy delays the senescence phenotype, including senescence-associated secretion. Our data suggest that autophagy, and its consequent protein turnover, mediate the acquisition of the senescence phenotype."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.519709"xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.519709"xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Kirschner K."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Kirschner K."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Shimizu S."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Shimizu S."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Tavare S."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Tavare S."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Narita M."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Narita M."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Watt F.M."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Watt F.M."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Arakawa S."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Arakawa S."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Ferreira M."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Ferreira M."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Young A.R."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Young A.R."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Sadaie M."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Sadaie M."xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Narita M.'"xsd:string |
| http://purl.uniprot.org/citations/19279323 | http://purl.uniprot.org/core/author | "Narita M.'"xsd:string |