| http://purl.uniprot.org/citations/19285079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19285079 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoclasts differentiate from macrophage-lineage cells to become specialized for bone resorption function. By a proteomics approach, we found that Lyn was down-regulated by the osteoclast differentiation factor, receptor activator of NF-kappaB ligand (RANKL). The forced reduction of Lyn caused a striking increase in the RANKL-induced PLCgamma1, Ca(2+), and NFATc1 responses during differentiation. These data suggest that Lyn plays a negative role in osteoclastogenesis by interfering with the PLCgamma1-mediated Ca(2+) signaling that leads to NFATc1 activation. Consistent with the in vitro results, in vivo injection of Lyn specific siRNA into mice calvariae provoked a fulminant bone resorption. Our study provides the first evidence of the involvement of Lyn in the negative regulation of osteoclastogenesis by RANKL."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2009.03.005"xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/author | "Lee Y."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/author | "Yoon S.H."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/author | "Lee Z.H."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/author | "Hyung S.W."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/author | "Kim H.H."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/pages | "1164-1170"xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/title | "Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling."xsd:string |
| http://purl.uniprot.org/citations/19285079 | http://purl.uniprot.org/core/volume | "583"xsd:string |
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