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http://purl.uniprot.org/citations/19285969http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19285969http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19285969http://www.w3.org/2000/01/rdf-schema#comment"Previously we have reported the accumulation of an N-terminal fragment of the TATA-box binding protein (TBP) in Alzheimer's disease brain tissue and here we report the identification of a naturally occurring TBP splice variant as a likely mechanism for its production. The splice variant described here encodes the polyglutamine-containing N-terminal domain of this key transcription factor. We demonstrate the expression of the splice variant mRNA in a variety of human tissues and that the resulting protein forms inclusions in cell culture transfection studies. The unusual properties of the variant protein suggest that it may be functionally relevant in late onset neurodegenerative diseases."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.org/dc/terms/identifier"doi:10.1016/j.brainres.2009.03.004"xsd:string
http://purl.uniprot.org/citations/19285969http://purl.org/dc/terms/identifier"doi:10.1016/j.brainres.2009.03.004"xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/author"Reid S.J."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/author"Reid S.J."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/author"Snell R.G."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/author"Snell R.G."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/author"Whittaker D.J."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/author"Whittaker D.J."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/author"Greenwood D."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/author"Greenwood D."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/name"Brain Res."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/name"Brain Res"xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/pages"190-199"xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/pages"190-199"xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/title"A splice variant of the TATA-box binding protein encoding the polyglutamine-containing N-terminal domain that accumulates in Alzheimer's disease."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/title"A splice variant of the TATA-box binding protein encoding the polyglutamine-containing N-terminal domain that accumulates in Alzheimer's disease."xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/volume"1268"xsd:string
http://purl.uniprot.org/citations/19285969http://purl.uniprot.org/core/volume"1268"xsd:string
http://purl.uniprot.org/citations/19285969http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19285969
http://purl.uniprot.org/citations/19285969http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19285969