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http://purl.uniprot.org/citations/19286759http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19286759http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

We evaluated the association between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type 1 (AT( 1))-receptor A1166C polymorphisms.

Methods

Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer.

Results

The frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, chi(2)); and for AT(1)receptor were:AA,AC and CC (in %: cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, chi( 2)).The results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls.

Conclusions

The ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes.The ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible target for developing genetic markers for breast cancer."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.org/dc/terms/identifier"doi:10.1177/1470320309102317"xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/author"Nogueira-de-Souza N.C."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/author"Vieira Gomes M.T."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/author"Alves Correa S.A."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/author"Guerreiro da Silva I.D."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/author"Juvenal Linhares J."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/author"Massad Costa A.M."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/author"Ribeiro de Noronha S.M."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/author"Valleta de Carvalho C."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/name"J Renin Angiotensin Aldosterone Syst"xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/pages"51-58"xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/title"Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women."xsd:string
http://purl.uniprot.org/citations/19286759http://purl.uniprot.org/core/volume"10"xsd:string
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