| http://purl.uniprot.org/citations/19289595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19289595 | http://www.w3.org/2000/01/rdf-schema#comment | "CD103 is characteristically expressed in hairy cell leukemia (HCL), a B-lymphoproliferative disorder highly responsive to treatment with purine analogs. Other CD103+ diseases are rare and do not respond well to the same therapy, including HCL variant (HCLv) and splenic marginal zone B-cell lymphoma (SMZL) variants. We analyzed 215 cases of CD103+ B-lymphoproliferative disorders to further delineate their immunophenotypic features. Flow cytometric analysis revealed that 78.6% of all cases expressed CD25 and CD103, characteristic of classical HCL. Cases analyzed immunohistochemically were also invariably positive for annexin-A1; a subset coexpressed CD10 (33/169 [19.5%]) or BCL1 (26/65 [36.9%]). In contrast, 21.4% of cases lacked CD25, a subset of which was analyzed and was invariably negative for annexin-A1, CD10, and BCL1. The CD25-cases had variable morphologic features ranging from HCLv and SMZL to prolymphocytic leukemia and diffuse large B-cell lymphoma. Clinically, patients with CD25-disease tended to be older (P= .001), typically had leukocytosis (P= .014), and did not respond well to cladribine or pentostatin. We suggest categorizing CD103+ B-lymphoproliferative disorders into 2 groups. While HCL coexpresses CD25 and annexin-A1, diseases lacking CD25 and annexin-A1 behave clinically differently and can be separated from HCL on diagnosis."xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.org/dc/terms/identifier | "doi:10.1309/ajcpl13yduhfkpju"xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/author | "Dong H.Y."xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/author | "Tugulea S."xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/author | "Weisberger J."xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/name | "Am J Clin Pathol"xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/pages | "586-595"xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/title | "Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics."xsd:string |
| http://purl.uniprot.org/citations/19289595 | http://purl.uniprot.org/core/volume | "131"xsd:string |
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