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http://purl.uniprot.org/citations/19289703http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19289703http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To examine the role of TESTIN as a candidate tumor suppressor gene in head and neck carcinogenesis.

Design

Mutation and messenger RNA (mRNA) expression analyses.

Setting

Academic research.

Patients

Paired normal and tumor samples were obtained from 38 patients with primary head and neck squamous cell carcinoma.

Main outcome measures

Analysis and comparison of TESTIN gene mRNA expression and its relationship to clinicopathologic variables.

Results

Mutation analysis showed a nucleotide and amino acid change in 6 of the 38 tumor samples (16.0%). Semiquantitative mRNA expression analysis of TESTIN revealed a decreased expression in approximately 50% of the tumors compared with their matched normal controls. Interestingly, comparison of clinicopathologic variables to mRNA expression status of TESTIN revealed a significant difference in terms of cancer history (P = .03). Moreover, a higher smoking ratio and a family cancer history were also associated with downregulation of TESTIN, although the difference was not statistically significant (P = .43 and P = .16, respectively). Kaplan-Meier survival analysis demonstrated a worse survival rate among the patients with low TESTIN expression compared with the patients with normal-high TESTIN expression.

Conclusions

Our findings suggest that inactivation of TESTIN is involved in head and neck carcinogenesis through its downregulation. Further studies in various human cancer tissues using a large sample size and in vitro functional studies as well as clinical comparison research studies would give us a better evaluation of TESTIN's role and its possible future application in molecular diagnosis and treatment of different cancer types, including head and neck squamous cell carcinoma."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.org/dc/terms/identifier"doi:10.1001/archoto.2008.560"xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Fukushima K."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Shimizu K."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Yamanaka N."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Nagai N."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Gunduz M."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Nagatsuka H."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Delibas N."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Sutcu R."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Gunduz E."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/author"Beder L."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/name"Arch Otolaryngol Head Neck Surg"xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/pages"254-260"xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/title"Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma."xsd:string
http://purl.uniprot.org/citations/19289703http://purl.uniprot.org/core/volume"135"xsd:string
http://purl.uniprot.org/citations/19289703http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19289703
http://purl.uniprot.org/citations/19289703http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19289703
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