| http://purl.uniprot.org/citations/19289819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19289819 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN gamma production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-17 antibodies, COX inhibitors, IL-12, or IFNgamma but was enhanced by prostaglandin E(2) (PGE(2)). IL-23-induced IL-17 production was increased by PGE(2) and suppressed by COX-inhibition or IL-12. Furthermore, COX inhibition failed to reduce IL-23-induced neutrophil migration in IL-12- or IFNgamma-deficient mice. IL-17-induced neutrophil migration was not affected by COX inhibitors, IL-12, or IFNgamma but was inhibited by MK886 (a leukotriene synthesis inhibitor), anti-TNFalpha, anti-CXCL1, and anti-CXCL5 antibodies and by repertaxin (a CXCR1/2 antagonist). These treatments all inhibited mBSA- or IL-23-induced neutrophil migration. IL-17 induced neutrophil chemotaxis through a CXC chemokines-dependent pathway. Our results suggest that prostaglandin plays an important role in IL-23-induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNgamma production. We thus provide a mechanism for the pathogenic role of the IL-23/IL-17 axis in RA and also suggest an additional mechanism of action for nonsteroidal anti-inflammatory drugs."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0812782106"xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Cunha F.Q."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Vieira S.M."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Liew F.Y."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "McInnes I.B."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Cunha T.M."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Ferreira S.H."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Verri W.A. Jr."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Fernandes K.S."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Souto F.O."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Grespan R."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/author | "Lemos H.P."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/pages | "5954-5959"xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/title | "Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production."xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19289819 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19289819 |
| http://purl.uniprot.org/citations/19289819 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19289819 |
| http://purl.uniprot.org/uniprot/Q9EQ14#attribution-38255E417C8E6A426250EB24AD36C6DA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19289819 |
| http://purl.uniprot.org/uniprot/#_E9QA93-mappedCitation-19289819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19289819 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW45-mappedCitation-19289819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19289819 |
| http://purl.uniprot.org/uniprot/#_E9Q6H6-mappedCitation-19289819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19289819 |