| http://purl.uniprot.org/citations/19295156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19295156 | http://www.w3.org/2000/01/rdf-schema#comment | "The involvement of matrix metalloproteinase-9 (MMP-9) activities in the development of abnormal water diffusion in the brain after cardiac arrest is not fully understood. We used magnetic resonance imaging to determine the correlation between MMP-9 activity and the mechanism of abnormal water diffusion after global cerebral ischemia (GCI)-induced brain damage in C57black6 mice. We induced GCI in mice by occluding both carotid arteries for 60 min, then allowing reperfusion. We labeled a short DNA that targets mmp-9 mRNA activity [phosphorothioate-modified oligodeoxynucleotide (sODN)-mmp9] or a control probe without intracellular target (sODN-Ran) with iron-based MR contrast agent [superparamagnetic iron oxide nanoparticle (SPION)-mmp9 or SPION-Ran] or fluorescein isothiocyanate (FITC)-sODN-mmp9 or FITC-sODN-Ran; we then delivered these probes by intracerebroventricular infusion or intraperitoneal injection within 3 h of reperfusion. At low dose (120 pmol/kg) the SPION-mmp9 probe was retained at significant levels in the striatum and cortex of living brains 10 h after GCI. Probe retention was validated by similar elevation of mmp-9 mRNA and antigens in postmortem samples taken from regions that exhibited GCI-induced hyperintensity in diffusion-weighted imaging, and a significant reduction in apparent diffusion coefficient (rADC, p = 0.0006, n = 12). At a higher dose (120 nmol/kg), the FITC-sODN-mmp9 probe revealed significant knockdown of MMP-9 activity, per zymography, and a reversal of striatal rADC (p = 0.004, n = 6). These observations were not duplicated in the control group. We conclude that expression of mmp-9 mRNA is associated with abnormal ADC after GCI."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5332-08.2009"xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/author | "Liu C.M."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/author | "Kim Y.R."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/author | "Liu C.H."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/author | "You Z."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/author | "Rosen B.R."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/author | "Whalen M.J."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/author | "Liu P.K."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/pages | "3508-3517"xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/title | "Diffusion-weighted magnetic resonance imaging reversal by gene knockdown of matrix metalloproteinase-9 activities in live animal brains."xsd:string |
| http://purl.uniprot.org/citations/19295156 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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