| http://purl.uniprot.org/citations/19297616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19297616 | http://www.w3.org/2000/01/rdf-schema#comment | "The transporter associated with antigen processing (TAP) represents a focal point in the immune recognition of virally or malignantly transformed cells by translocating proteasomal degradation products into the endoplasmic reticulum-lumen for loading of MHC class I molecules. Based on a number of experimental data and the homology to the bacterial ABC exporter Sav1866, we constructed a 3D structural model of the core TAP complex and used it to examine the interface between the transmembrane and nucleotide-binding domains (NBD) by cysteine-scanning and cross-linking approaches. Herein, we demonstrate the functional importance of the newly identified X-loop in the NBD in coupling substrate binding to downstream events in the transport cycle. We further verified domain swapping in a heterodimeric ABC half-transporter complex by cysteine cross-linking. Strikingly, either substrate binding or translocation can be blocked by cross-linking the X-loop to coupling helix 2 or 1, respectively. These results resolve the structural arrangement of the transmission interface and point to different functions of the cytosolic loops and coupling helices in substrate binding, signaling, and transport."xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0811260106"xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/author | "O'Mara M.L."xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/author | "Abele R."xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/author | "Tampe R."xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/author | "Tieleman D.P."xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/author | "Bennett W.F."xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/author | "Oancea G."xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/pages | "5551-5556"xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/title | "Structural arrangement of the transmission interface in the antigen ABC transport complex TAP."xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19297616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19297616 |
| http://purl.uniprot.org/citations/19297616 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19297616 |
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| http://purl.uniprot.org/uniprot/#_A0A1V0E3X6-mappedCitation-19297616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19297616 |
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