| http://purl.uniprot.org/citations/19298601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19298601 | http://www.w3.org/2000/01/rdf-schema#comment | "The authors investigated the status of abnormalities of eIF-5A2 gene in superficial (pTa/pT1) urothelial carcinoma of the bladder (UC), as well as its correlation with clinicopathologic variables and patient outcome. The methods of immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting were utilized to examine protein/mRNA(messenger RNA) expression and amplification of eIF-5A2 in a cohort of pTa/pT1 UCs. Overexpression of EIF-5A2 was examined by IHC in 38/112 (33.9%) pTa/pT1 UCs. A significant association of overexpression of EIF-5A2 with shortened UC patient recurrence-free survival (P = 0.002), as well as with shortened progression-free survival (P = 0.004), was demonstrated. Importantly, multivariate Cox regression analysis revealed that EIF-5A2 expression provided a significant independent prognostic parameter either in tumor recurrence (P = 0.002) or in tumor progression (P = 0.007). FISH results demonstrated that eIF-5A2 amplification was detected in 5/59 of the informative UCs; in each of the five cases with eIF-5A2 amplification, overexpression of EIF-5A2 was observed. In the remaining 54 UCs without eIF-5A2 amplification, 16 cases were also observed to have overexpression of EIF-5A2. In 13 pairs of UC and adjacent normal tissues, eight UCs were examined and showed up-regulated eIF-5A2 mRNA by RT-PCR, while increased expression of EIF-5A2 protein was only detected in 4/8 UCs by Western blotting. These findings suggest that overexpression of EIF-5A2, as detected by IHC, may predict tumor recurrence and progression in pTa/pT1 UC patients, and the protein expression of eIF-5A2 might be regulated not only by gene amplification, but also by other molecular mechanisms."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2009.01126.x"xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Zeng Y.X."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Xie D."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Kung H.F."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Liao Y.J."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Guan X.Y."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Luo J.H."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Hua W.F."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/author | "Rao H.L."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/pages | "896-902"xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/title | "Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder."xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/19298601 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19298601 |
| http://purl.uniprot.org/citations/19298601 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19298601 |
| http://purl.uniprot.org/uniprot/#_Q9GZV4-mappedCitation-19298601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19298601 |
| http://purl.uniprot.org/uniprot/Q9GZV4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19298601 |