| http://purl.uniprot.org/citations/19299583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19299583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19299583 | http://www.w3.org/2000/01/rdf-schema#comment | "The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the light-dark cycle. Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice. Inhibition of NAMPT promotes oscillation of the clock gene Per2 by releasing CLOCK:BMAL1 from suppression by SIRT1. In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1171641"xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1171641"xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Imai S."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Imai S."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Buhr E.D."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Buhr E.D."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Abrassart D."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Abrassart D."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Bass J."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Bass J."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Brace C.S."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Brace C.S."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Chong J.L."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Chong J.L."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Hong H.K."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Hong H.K."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Marcheva B."xsd:string |
| http://purl.uniprot.org/citations/19299583 | http://purl.uniprot.org/core/author | "Marcheva B."xsd:string |