| http://purl.uniprot.org/citations/19299915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19299915 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt pathways up-regulate MMP-9 expression, regulation of MMP-9 by JNK remains controversial. Presently, we aimed to determine the role of JNK in MMP-9 regulation in Raw 264.7 cells. Inhibition of JNK by the JNK inhibitor SP600125 induced MMP-9 in the absence of serum and suppressed the expression of TNF-alpha, IL-6 and cyclooxygenase-2 in LPS-treated Raw 264.7 cells. In a knockdown experiment with small interfering RNA, suppression of JNK1 induced MMP-9 expression. Interestingly, mouse serum suppressed SP600125-mediated MMP-9 induction, similar to IFN-gamma. However, the inhibitory activity of mouse serum was not affected by pyridone 6, which inhibits Janus kinase downstream to IFN-gamma. In addition to mouse serum, conditioned media of Raw 264.7 cells contained the inhibitory factor(s) larger than 10 kDa, which suppressed SP600125- or LPS-induced MMP-9 expression. Taken together, these data suggest that JNK1 suppresses MMP-9 expression in the absence of serum. In addition, the inhibitory factor(s) present in serum or secreted from macrophages may negatively control MMP-9 expression."xsd:string |
| http://purl.uniprot.org/citations/19299915 | http://purl.org/dc/terms/identifier | "doi:10.3858/emm.2009.41.4.029"xsd:string |
| http://purl.uniprot.org/citations/19299915 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/19299915 | http://purl.uniprot.org/core/author | "Van Ta Q."xsd:string |
| http://purl.uniprot.org/citations/19299915 | http://purl.uniprot.org/core/author | "Lan Tran H.T."xsd:string |
| http://purl.uniprot.org/citations/19299915 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19299915 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/19299915 | http://purl.uniprot.org/core/pages | "259-268"xsd:string |
| http://purl.uniprot.org/citations/19299915 | http://purl.uniprot.org/core/title | "Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media."xsd:string |
| http://purl.uniprot.org/citations/19299915 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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