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http://purl.uniprot.org/citations/19304869http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19304869http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Pregnancy-associated plasma protein-A (PAPP-A) has been implicated in the atherosclerotic process through regulation of local expression of IGF1. In type 2 diabetes mellitus, glycaemic control has been involved in PAPP-A expression. We compared PAPP-A, IGF1, inflammatory markers and adiponectin concentrations in type 2 diabetic patients with and without carotid plaques and evaluated the relationship between these serum parameters and ultrasound carotid markers of atherosclerosis.

Methods

We studied 125 consecutive type 2 diabetic patients. Clinical data, metabolic variables, hemostatic factors (plasma type-1 plasminogen activator inhibitor, fibrinogen), high-ultrasensitive C reactive protein (hsCRP), tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, adiponectin, IGF1 and PAPP-A were determined. Patients were classified into two groups according to the presence of carotid plaques on ultrasound. Carotid intima-media thickness (IMT) and morphology of carotid plaques were evaluated.

Results

The mean age was 61.5+/-7.3 years and the mean glycated hemoglobin of 6.8+/-0.9%. A total of 60% presented carotid plaques. Both groups were homogeneous in anthropometric data, biochemical determinations and hemostatic factors. Adiponectin, hsCRP, TNF-alpha and IL-6 were similar in both groups. No differences were observed in serum PAPP-A (0.46 (0.22-0.86) vs 0.38 (0.18-0.66) mIU/l and in SDS IGF1 (-0.34+/-1.38 vs -0.67+/-1.35)) in patients with and without carotid plaques respectively. PAPP-A and IGF1 were not correlated with IMT.

Conclusions

Serum PAPP-A and IGF1 do not appear to be useful serum biomarkers for carotid atherosclerosis in type 2 diabetic patients with stable glycemic control, despite scientific evidence of their local role in atherosclerosis."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.org/dc/terms/identifier"doi:10.1530/eje-09-0097"xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Salinas I."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Reverter J.C."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Pizarro E."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Tassies D."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Pastor M.C."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Sanmarti A."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Granada M.L."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Pellitero S."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/author"Reverter J.L."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/name"Eur J Endocrinol"xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/pages"925-932"xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/title"Association of the IGF1/pregnancy-associated plasma protein-A system and adipocytokine levels with the presence and the morphology of carotid plaques in type 2 diabetes mellitus patients with stable glycaemic control."xsd:string
http://purl.uniprot.org/citations/19304869http://purl.uniprot.org/core/volume"160"xsd:string
http://purl.uniprot.org/citations/19304869http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19304869
http://purl.uniprot.org/citations/19304869http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19304869
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