| http://purl.uniprot.org/citations/19307756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19307756 | http://www.w3.org/2000/01/rdf-schema#comment | "To select candidate genes, we attempted to comparative analysis of protein levels between rheumatoid arthritis (RA) patients and healthy controls by two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF-MS). We identified 17 proteins that showed up- or down-regulated spots in RA patients. We found that coactosin-like1 (COTL1) were highly expressed in RA patients compared with healthy controls. We performed a case-control study to determine whether the COTL1 gene polymorphisms were associated with RA and systemic lupus erythematosus (SLE). The genotype frequency of c.-1124G>T and the allelic frequency of c.484G>A in RA patients, and the genotype frequency of c.484G>A in SLE patients were significantly different from healthy controls (P=0.009, 0.027, and 0.025, respectively). We also investigated the correlation with the levels of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody in RA patients, and anti-nuclear antibodies (ANA) in SLE patients. The c.484G>A polymorphism in RA patients has significant association with the levels of anti-CCP antibody (P=0.03). Our findings demonstrated that c.-1124G>T and c. 484G>A polymorphisms of the COTL1 gene might be associated with the genetic susceptibility of autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.org/dc/terms/identifier | "doi:10.3858/emm.2009.41.5.040"xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/author | "Chae S.C."xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/author | "Kim H.G."xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/author | "Chung H.T."xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/author | "Shim S.C."xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/author | "Jin E.H."xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/pages | "354-361"xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/title | "Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/19307756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19307756 |
| http://purl.uniprot.org/citations/19307756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19307756 |
| http://purl.uniprot.org/uniprot/#_A0A384MTY2-mappedCitation-19307756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19307756 |
| http://purl.uniprot.org/uniprot/#_Q14019-mappedCitation-19307756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19307756 |
| http://purl.uniprot.org/uniprot/A0A384MTY2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19307756 |
| http://purl.uniprot.org/uniprot/Q14019 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19307756 |