| http://purl.uniprot.org/citations/19323994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19323994 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple excitatory and inhibitory interneurons form the motor circuit with motor neurons in the ventral spinal cord. Notch signaling initiates the diversification of immature V2-interneurons into excitatory V2a-interneurons and inhibitory V2b-interneurons. Here, we provide a transcriptional regulatory mechanism underlying their balanced production. LIM-only protein LMO4 controls this binary cell fate choice by regulating the activity of V2a- and V2b-specific LIM complexes inversely. In the spinal cord, LMO4 induces GABAergic V2b-interneurons in collaboration with SCL and inhibits Lhx3 from generating glutamatergic V2a-interneuons. In LMO4;SCL compound mutant embryos, V2a-interneurons increase markedly at the expense of V2b-interneurons. We further demonstrate that LMO4 nucleates the assembly of a novel LIM-complex containing SCL, Gata2, and NLI. This complex activates specific enhancers in V2b-genes consisting of binding sites for SCL and Gata2, thereby promoting V2b-interneuron fate. Thus, LMO4 plays essential roles in directing a balanced generation of inhibitory and excitatory neurons in the ventral spinal cord."xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2009.02.011"xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/author | "Lee J.W."xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/author | "Lee B."xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/author | "Lee S.K."xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/author | "Joshi K."xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/pages | "839-851"xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/title | "LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons."xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/19323994 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19323994 |
| http://purl.uniprot.org/citations/19323994 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19323994 |
| http://purl.uniprot.org/uniprot/O09100#attribution-04ADB6842DB3C077E98684FA8EA33F70 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19323994 |
| http://purl.uniprot.org/uniprot/P70662#attribution-04ADB6842DB3C077E98684FA8EA33F70 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19323994 |
| http://purl.uniprot.org/uniprot/P70662#attribution-59485EC99BFE9E5505D66BBFA9E6B75F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19323994 |
| http://purl.uniprot.org/uniprot/P50481#attribution-04ADB6842DB3C077E98684FA8EA33F70 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19323994 |
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| http://purl.uniprot.org/uniprot/P22091#attribution-04ADB6842DB3C077E98684FA8EA33F70 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19323994 |
| http://purl.uniprot.org/uniprot/P22091#attribution-B772C7C5CC2B6BF6A7882F3E9580AA78 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19323994 |
| http://purl.uniprot.org/uniprot/Q9D032#attribution-04ADB6842DB3C077E98684FA8EA33F70 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19323994 |