| http://purl.uniprot.org/citations/19324877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19324877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19324877 | http://www.w3.org/2000/01/rdf-schema#comment | "The TAZ transcription co-activator has been shown to promote cell proliferation and to induce epithelial-mesenchymal transition. Recently we have demonstrated that TAZ is phosphorylated and inhibited by the Hippo tumor suppressor pathway, which is altered in human cancer. The mechanism of TAZ-mediated transcription is unclear. We demonstrate here that TEAD is a key downstream transcription factor mediating the function of TAZ. Disruption of TEAD-TAZ binding or silencing of TEAD expression blocked the function of TAZ to promote cell proliferation and to induce epithelial-mesenchymal transition, demonstrating TEAD as a key downstream effector of TAZ. We also identified CTGF, a gene that regulates cell adhesion, proliferation, and migration, as a direct target of TAZ and TEAD. Our study establishes a functional partnership between TAZ and TEAD under negative regulation by the Hippo signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m900843200"xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m900843200"xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Liu C.Y."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Liu C.Y."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Lei Q.Y."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Lei Q.Y."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Zha Z.Y."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/author | "Zha Z.Y."xsd:string |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19324877 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |