| http://purl.uniprot.org/citations/19325136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19325136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19325136 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) increases or decreases nuclear factor kappa B (NFkappaB) signaling in a context-dependent manner through mechanisms that remain to be defined. The type III transforming growth factor-beta receptor (TbetaRIII) is a TGF-beta superfamily co-receptor with emerging roles in both mediating and regulating TGF-beta superfamily signaling. We have previously reported a novel interaction of TbetaRIII with the scaffolding protein, beta-arrestin2, which results in TbetaRIII internalization and downregulation of TGF-beta signaling. beta-arrestin2 also scaffolds interacting receptors with the mitogen-activated protein kinase and NFkappaB-signaling pathways. Here, we demonstrate that TbetaRIII, through its interaction with beta-arrestin2, negatively regulates NFkappaB signaling in MCF10A breast epithelial and MDA-MB-231 breast cancer cells. Increasing TbetaRIII expression reduced NFkappaB-mediated transcriptional activation and IkappaBalpha degradation, whereas a TbetaRIII mutant unable to interact with beta-arrestin2, TbetaRIII-T841A, had no effect. In a reciprocal manner, short hairpin RNA-mediated silencing of either TbetaRIII expression or beta-arrestin2 expression increased NFkappaB-mediated transcriptional activation and IkappaBalpha degradation. Functionally, TbetaRIII-mediated repression of NFkappaB signaling is important for TbetaRIII-mediated inhibition of breast cancer cell migration. These studies define a mechanism through which TbetaRIII regulates NFkappaB signaling and expand the roles of this TGF-beta superfamily co-receptor in regulating epithelial cell homeostasis."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgp071"xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgp071"xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/author | "Blobe G.C."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/author | "Blobe G.C."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/author | "How T."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/author | "How T."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/author | "You H.J."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/author | "You H.J."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/pages | "1281-1287"xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/pages | "1281-1287"xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/title | "The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/title | "The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2."xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/19325136 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19325136 |
| http://purl.uniprot.org/citations/19325136 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19325136 |
| http://purl.uniprot.org/citations/19325136 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19325136 |
| http://purl.uniprot.org/citations/19325136 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19325136 |