| http://purl.uniprot.org/citations/19326408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19326408 | http://www.w3.org/2000/01/rdf-schema#comment | "In 20% to 30% of infected individuals, hepatitis C virus (HCV) can cause cirrhosis and hepatocellular carcinoma, for which liver transplantation is the best treatment available. HCV re-infection is universal, and hepatitis disease recurrence occurs in most cases with a 30% probability of progression to graft cirrhosis at 5 years post-transplant. The immunological response to HCV involves natural killer (NK) cells and killer cell immunoglobulin-like receptors (KIRs), which specifically recognize human leukocyte antigen (HLA) class I antigens present on target cells. The effector functions of NK cells are influenced by inhibitory KIR interaction with self-HLA class I ligands, with HLA-C being the most predominant. This study examines the roles of KIR genotypes and their HLA ligands in both HCV disease recurrence and its progression. A total of 151 patients were included in the cohort, and their clinical details were recorded. Liver biopsies were used to define the absence/presence of recurrent hepatitis, the degree of fibrosis, and the progression to cirrhosis over a 10-year period. Mismatching of KIR-HLA-C ligands between donor-recipient pairs was associated with the recurrence of hepatitis (P = 0.008). The presence of KIR2DL3 in the recipient correlated with progression to liver fibrosis (P = 0.04). The mismatching of HLA-KIR ligands favored the progression of the recurrent hepatitis to fibrosis only in the presence of KIR2DL3 (P = 0.04). These preliminary results indicate that the KIR genotype and KIR-HLA-C ligand compatibility play roles in the recurrence and progression of hepatitis C disease in liver transplant recipients."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.org/dc/terms/identifier | "doi:10.1002/lt.21673"xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Torelli R."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Poli F."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Burra P."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Scalamogna M."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "de Arias A.E."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Guido M."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Cardillo M."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Haworth S.E."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Pinzello G."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Vangeli M."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Belli L.S."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Boccagni P."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "De Feo T.M."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/author | "Minola E."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/name | "Liver Transpl"xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/pages | "390-399"xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/title | "Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation."xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/19326408 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19326408 |
| http://purl.uniprot.org/citations/19326408 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19326408 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-19326408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19326408 |