| http://purl.uniprot.org/citations/19326813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19326813 | http://www.w3.org/2000/01/rdf-schema#comment | "Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Rs6295C/G SNP in the 5-HT1A gene (HTR1A) has been found to affect the expression and function of HTR1A. In fact rs6295C/G is in strong linkage disequilibrium with other polymorphisms of HTR1A suggesting that those functional effects could be associated with polymorphisms other than or together with the synonymous rs6295C/G. In the present study we examined the possible association of a panel of markers in strong linkage disequilibrium of HTR1A with SSRI/SNRI response in 137 Japanese major depression subjects followed for 6 weeks. We observed a significant association of better response to antidepressant in rs10042486C/C (P < 0.0001), rs6295G/G (P < 0.0001) and rs1364043T/T (P = 0.018) genotype carriers, independently from clinical variables. Furthermore minor allele homozygous carriers in all these 3 SNPs were associated with treatment response by various assessments such as HAM-D score change over time (P = 0.001), week 2 (P < 0.0001), 4 (P = 0.007), and 6 (P = 0.048) as well as response rate (P = 0.0005) and remission rate (P = 0.004). We also pointed out the genotyping mis-definition of rs6295C/G in the previous four papers."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/author | "Fukuda T."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/author | "Kinoshita T."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/author | "Azuma J."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/author | "Serretti A."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/author | "Wakeno M."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/author | "Okugawa G."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/author | "Takekita Y."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/name | "Nihon Shinkei Seishin Yakurigaku Zasshi"xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/pages | "23-31"xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/title | "[5-HT1A gene polymorphisms contributed to antidepressant response in major depression]."xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19326813 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19326813 |
| http://purl.uniprot.org/citations/19326813 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19326813 |
| http://purl.uniprot.org/uniprot/#_A0N5V3-mappedCitation-19326813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19326813 |
| http://purl.uniprot.org/uniprot/#_A8K5W4-mappedCitation-19326813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19326813 |
| http://purl.uniprot.org/uniprot/#_Q5ZGX3-mappedCitation-19326813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19326813 |
| http://purl.uniprot.org/uniprot/#_P08908-mappedCitation-19326813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19326813 |
| http://purl.uniprot.org/uniprot/P08908 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19326813 |
| http://purl.uniprot.org/uniprot/A8K5W4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19326813 |
| http://purl.uniprot.org/uniprot/Q5ZGX3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19326813 |
| http://purl.uniprot.org/uniprot/A0N5V3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19326813 |