| http://purl.uniprot.org/citations/19327357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19327357 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the effect of liver X receptor (LXR) agonists on vascular calcification, prevalent in atherosclerotic lesions. T0901317, an LXR agonist, augmented protein kinase A (PKA)-induced mineralization and alkaline phosphatase (ALP) activity in aortic smooth muscle cells isolated from wild-type, but not from Lxrbeta(-/-)mice. A six-hour T0901317 treatment augmented the PKA-induced expression of the phosphate transporter Pit-1, a positive regulator of mineralization, suggesting a direct role. A ten-day T0901317 treatment attenuated PKA-induced expression of mineralization inhibitors, osteopontin and ectonucleotide pyrophosphatase/phosphodiesterase-1, suggesting an indirect role. The effects of T0901317 were attenuated by inhibition of ALP, Pit-1 and Rho-associated kinase, but not by inhibition of PKA. These results suggest that T0901317-augmented mineralization occurs downstream of PKA, involving both direct and indirect LXR-mediated pathways."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2009.03.039"xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Geng Y."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Huang M.S."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Tontonoz P."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Bradley M.N."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Demer L.L."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Tintut Y."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Hsu J.J."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/author | "Sage A.P."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/pages | "1344-1348"xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/title | "T0901317, an LXR agonist, augments PKA-induced vascular cell calcification."xsd:string |
| http://purl.uniprot.org/citations/19327357 | http://purl.uniprot.org/core/volume | "583"xsd:string |
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