| http://purl.uniprot.org/citations/19327994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19327994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19327994 | http://www.w3.org/2000/01/rdf-schema#comment | "The Bcl-2 family proteins are critical apoptosis regulators that associate with mitochondria and control the activation of caspases. Recently, both mammalian and C. elegans Bcl-2 proteins have been implicated in controlling mitochondrial fusion and fission processes in both living and apoptotic cells. To better understand the potential roles of Bcl-2 family proteins in regulating mitochondrial dynamics, we carried out a detailed analysis of mitochondria in animals that either lose or have increased activity of egl-1 and ced-9, two Bcl-2 family genes that induce and inhibit apoptosis in C. elegans, respectively. Unexpectedly, we found that loss of egl-1 or ced-9, or overexpression of their gene products, had no apparent effect on mitochondrial connectivity or mitochondrial size. Moreover, loss of ced-9 did not affect the mitochondrial morphology observed in a drp-1 mutant, in which mitochondrial fusion occurs but mitochondrial fission is defective, or in a fzo-1 mutant, in which mitochondrial fission occurs but mitochondrial fusion is restricted, suggesting that ced-9 is not required for either the mitochondrial fission or fusion process in C. elegans. Taken together, our results argue against an evolutionarily conserved role for Bcl-2 proteins in regulating mitochondrial fission and fusion."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.03.022"xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.03.022"xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/author | "Kang B.H."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/author | "Kang B.H."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/author | "Breckenridge D.G."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/author | "Breckenridge D.G."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/pages | "768-773"xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/pages | "768-773"xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/title | "Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/title | "Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/19327994 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19327994 |
| http://purl.uniprot.org/citations/19327994 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19327994 |
| http://purl.uniprot.org/citations/19327994 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19327994 |
| http://purl.uniprot.org/citations/19327994 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19327994 |