| http://purl.uniprot.org/citations/19328020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19328020 | http://www.w3.org/2000/01/rdf-schema#comment | "A unique subpopulation of spleen dendritic cells (DCs) that express the CD8 surface marker efficiently present phagocytosed antigens to CD8(+) T lymphocytes in a process called "crosspresentation," which initiates cytotoxic immune responses. We now show that the small GTPase Rac2 plays a critical role in antigen crosspresentation selectively in this DC subpopulation. In CD8(+) DCs, Rac2 determines the subcellular assembly of the NADPH oxidase complex (NOX2) to phagosomes, whereas in CD8(-) DCs, Rac1 mediates the assembly of NOX2 at the plasma membrane. In the absence of Rac2, the production of reactive oxygen species (ROS) in DC-phagosomes was abolished, the phagosomal pH dropped, and the efficiency of antigen crosspresentation was reduced. We conclude that the activity of Rac1 and 2 control crosspresentation in DC subpopulations through the regulation of phagosomal oxidation and pH."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2009.01.013"xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/author | "Moita C."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/author | "Hacohen N."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/author | "Peres A."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/author | "Moita L.F."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/author | "Amigorena S."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/author | "Carmo N."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/author | "Savina A."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/author | "Cebrian I."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/pages | "544-555"xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/title | "The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/19328020 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19328020 |
| http://purl.uniprot.org/citations/19328020 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19328020 |
| http://purl.uniprot.org/uniprot/#_E9Q7S3-mappedCitation-19328020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19328020 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VH29-mappedCitation-19328020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19328020 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHH0-mappedCitation-19328020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19328020 |
| http://purl.uniprot.org/uniprot/#_E9Q802-mappedCitation-19328020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19328020 |
| http://purl.uniprot.org/uniprot/#_Q3U4P0-mappedCitation-19328020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19328020 |
| http://purl.uniprot.org/uniprot/#_Q05144-mappedCitation-19328020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19328020 |
| http://purl.uniprot.org/uniprot/#_Q3TVP4-mappedCitation-19328020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19328020 |