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http://purl.uniprot.org/citations/19329498http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19329498http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2) is a glycoprotein with bacteriostatic properties. Growing evidence suggests that NGAL may also be involved in cell survival, inflammation, and matrix degradation. We therefore aimed to investigate the role of NGAL in heart failure (HF).

Methods and results

Our main findings were (i) patients with acute post-myocardial infarction (MI) HF (n = 236) and chronic HF (n = 150) had elevated serum levels of NGAL (determined by enzyme immunoassay), significantly correlated with clinical and neurohormonal deterioration, (ii) in patients with HF following acute MI, elevated NGAL levels of at baseline were associated with adverse outcomes (median of 27 months follow-up), (iii) in a rat model of post-MI HF, NGAL/lipocalin-2 gene expression was increased in the non-ischaemic part of the left ventricle primarily located to cardiomyocytes, (iv) strong NGAL immunostaining was found in cardiomyocytes within the failing myocardium both in experimental and clinical HF, (v) interleukin-1beta and agonists for toll-like receptors 2 and 4, representing components of the innate immune system, were potent inducers of NGAL/lipocalin-2 in isolated neonatal cardiomyocytes.

Conclusion

Our demonstration of enhanced systemic and myocardial NGAL expression in clinical and experimental HF further support a role for innate immune responses in the pathogenesis of HF."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.org/dc/terms/identifier"doi:10.1093/eurheartj/ehp088"xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Christensen G."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Aukrust P."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Oie E."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Vinge L.E."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Husberg C."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Flo T.H."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Espevik T."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Ueland T."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Froland S.S."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Gullestad L."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Yndestad A."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Dickstein K."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Kjekshus J."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Dahl C.P."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/author"Landro L."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/name"Eur Heart J"xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/pages"1229-1236"xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/title"Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure."xsd:string
http://purl.uniprot.org/citations/19329498http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/19329498http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19329498
http://purl.uniprot.org/citations/19329498http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19329498
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