| http://purl.uniprot.org/citations/19330822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19330822 | http://www.w3.org/2000/01/rdf-schema#comment | "Brain effects of erythropoietin (Epo) are proposed to involve a heteromeric receptor comprising the classical Epo receptor (Epo-R) and the common beta chain (betac). However, data documenting the pattern of betac gene expression in the healthy brain, in comparison with that of the Epo-R gene, are still lacking. The present study is the first to investigate at the same time betac, Epo-R, and Epo gene expression within different rat brain areas throughout the life span, from neonatal to elderly stages, using quantitative RT-PCR for transcripts. Corresponding proteins were localized by using immunohistochemistry. We demonstrate that the betac transcript level does not correlate with that of Epo-R or Epo, whereas the Epo-R transcript level strongly correlates with that of Epo throughout the life span in all brain structures analyzed. Both Epo and Epo-R were detected primarily in neurons. In the hippocampus, the greatest Epo-R mRNA levels were measured during the early postnatal period and in middle-aged rats, associated with an intense neuronal immunolabeling. Conversely, betac protein was barely detectable in the brain at all ages, even in neurons expressing high levels of Epo-R. Finally, betac transcript could not be detected in PC12 cells, even after nerve growth factor-induced neuritogenesis, which is a condition that dramatically enhances Epo-R transcript level. Altogether, our data suggest that most neurons are likely to express high levels of Epo-R but low, if not null, levels of betac. Given that Epo protects extended populations of neurons after injury, a yet-to-be-identified receptor heterocomplex including Epo-R may exist in the large population of brain neurons that does not express betac."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.22020"xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Bonnet C."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Moulin C."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Morales A."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Georges B."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Bodennec J."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Ryvlin P."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Bezin L."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Belmeguenai A."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Fares R.P."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Le Cavorsin M."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Nadam J."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Navarro F.P."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/author | "Sanchez P.E."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/name | "J Comp Neurol"xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/pages | "403-414"xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/title | "Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life span."xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://purl.uniprot.org/core/volume | "514"xsd:string |
| http://purl.uniprot.org/citations/19330822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19330822 |
| http://purl.uniprot.org/citations/19330822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19330822 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GCI9-mappedCitation-19330822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19330822 |
| http://purl.uniprot.org/uniprot/#_O35545-mappedCitation-19330822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19330822 |