| http://purl.uniprot.org/citations/19332500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19332500 | http://www.w3.org/2000/01/rdf-schema#comment | "Light adaptation in vertebrate photoreceptors is mediated by multiple mechanisms, one of which could involve nuclear feedback and changes in gene expression. Therefore, we have investigated light adaptation-associated changes in gene expression using microarrays and real-time PCR in isolated photoreceptors, in cultured isolated retinas and in acutely isolated retinas. In all three preparations after 2 h of an exposure to a bright light, we observed an up-regulation of almost 100% of three genes, Sag, Guca1a and Guca1b, coding for proteins known to play a major role in phototransduction: arrestin, GCAP1 and GCAP2. No detectable up-regulation occurred for light exposures of less than 1 h. Functional in vivo electroretinographic tests show that a partial recovery of the dark current occurred 1-2 h after prolonged illumination with a steady light that initially caused a substantial suppression of the photoresponse. These observations demonstrate that prolonged illumination results in the up-regulation of genes coding for proteins involved in the phototransduction signalling cascade, possibly underlying a novel component of light adaptation occurring 1-2 h after the onset of a steady bright light."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.org/dc/terms/identifier | "doi:10.1113/jphysiol.2009.168609"xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/author | "Torre V."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/author | "Subkhankulova T."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/author | "Livesey F.J."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/author | "Cervetto L."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/author | "Gargini C."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/author | "Bedolla D.E."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/author | "Codega P."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/author | "Della Santina L."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/name | "J Physiol"xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/pages | "2457-2472"xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/title | "Prolonged illumination up-regulates arrestin and two guanylate cyclase activating proteins: a novel mechanism for light adaptation."xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://purl.uniprot.org/core/volume | "587"xsd:string |
| http://purl.uniprot.org/citations/19332500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19332500 |
| http://purl.uniprot.org/citations/19332500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19332500 |
| http://purl.uniprot.org/uniprot/#_D3ZII9-mappedCitation-19332500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19332500 |
| http://purl.uniprot.org/uniprot/#_A6JIK4-mappedCitation-19332500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19332500 |
| http://purl.uniprot.org/uniprot/#_P43081-mappedCitation-19332500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19332500 |
| http://purl.uniprot.org/uniprot/#_P20443-mappedCitation-19332500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19332500 |
| http://purl.uniprot.org/uniprot/#_Q3UEW3-mappedCitation-19332500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19332500 |
| http://purl.uniprot.org/uniprot/#_Q3UPX6-mappedCitation-19332500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19332500 |
| http://purl.uniprot.org/uniprot/#_Q8BPV0-mappedCitation-19332500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19332500 |