| http://purl.uniprot.org/citations/19332769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19332769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19332769 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelet P-selectin plays important roles in inflammation and contributes to thrombosis and hemostasis. Although it has been reported that von Willebrand factor (VWF) affects P-selectin expression on endothelial cells, little information is available regarding regulation of platelet P-selectin expression. Here, we first observed that P-selectin expression was significantly decreased on platelets of fibrinogen and VWF double-deficient mice. Subsequently, we identified this was due to fibrinogen deficiency. Impaired P-selectin expression on fibrinogen-deficient platelets was further confirmed in human hypofibrinogenemic patients. We demonstrated that this impairment is unlikely due to excessive P-selectin shedding, deficient fibrinogen-mediated cell surface P-selectin binding, or impaired platelet granule release, but rather is due to decreased platelet P-selectin content. Fibrinogen transfusion completely recovered this impairment in fibrinogen-deficient (Fg(-/-)) mice, and engagement of the C-terminus of the fibrinogen gamma chain with beta3 integrin was required for this process. Furthermore, Fg(-/-) platelets significantly increased P-selectin expression following transfusion into beta3 integrin-deficient mice and when cultured with fibrinogen. These data suggest fibrinogen may play important roles in inflammation, thrombosis, and hemostasis via enhancement of platelet P-selectin expression. Since human fibrinogen levels vary significantly in normal and diseased populations, P-selectin as an activation marker on platelets should be used with caution."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-03-145821"xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-03-145821"xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Lang S."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Lang S."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Ni H."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Ni H."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Degen J.L."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Degen J.L."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Zhai Z."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Zhai Z."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Kahr W.H."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Kahr W.H."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Flick M.J."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Flick M.J."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Spring C.M."xsd:string |
| http://purl.uniprot.org/citations/19332769 | http://purl.uniprot.org/core/author | "Spring C.M."xsd:string |