| http://purl.uniprot.org/citations/19333141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19333141 | http://www.w3.org/2000/01/rdf-schema#comment | "In severely injured and hypoperfused trauma patients, endogenous acute coagulopathy (EAC) is associated with an increased morbidity and mortality. Recent human data correlate this coagulopathy with activation of the protein C pathway. To examine the mechanistic role of protein C in the development of EAC, we used a mouse model of trauma and hemorrhagic shock, characterized by the combination of tissue injury and severe metabolic acidosis. Mice were subjected to one of four treatment groups: 1) C, control; 2) T, trauma (laparotomy); 3) H, hemorrhage (MAP, 35 mmHg x 60 min); 4) TH, trauma + hemorrhage. After 60 min, blood was drawn for analysis. Compared with C mice, the TH mice had a significantly elevated activated partial thromboplastin time (23.3 vs. 34.5 s) and significantly increased levels of activated protein C (aPC; 2.30 vs. 13.58 ng/mL). In contrast, T and H mice did not develop an elevated activated partial thromboplastin time or increased aPC. Selective inhibition of the anticoagulant property of aPC prevented the coagulopathy seen in response to trauma/hemorrhage (23.5 vs. 38.6 s [inhibitory vs. control monoclonal antibody]) with no impact on survival during the shock period. However, complete blockade of both the anticoagulant and cytoprotective functions of aPC caused 100% mortality within 45 min of shock, with histopathology evidence of pulmonary thrombosis and perivascular hemorrhage. These results indicate that our unique mouse model of T/H shock mimics our previous observations in trauma patients and demonstrates that EAC is mediated by the activation of the protein C pathway. In addition, the cytoprotective effect of protein C activation seems to be necessary for survival of the initial shock injury."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.org/dc/terms/identifier | "doi:10.1097/shk.0b013e3181a5a632"xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Chesebro B.B."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Cohen M.J."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Frith D."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Esmon C.T."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Pittet J.F."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Brohi K."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Carles M."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/author | "Rahn P."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/name | "Shock"xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/pages | "659-665"xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/title | "Increase in activated protein C mediates acute traumatic coagulopathy in mice."xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/19333141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19333141 |
| http://purl.uniprot.org/citations/19333141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19333141 |
| http://purl.uniprot.org/uniprot/#_P33587-mappedCitation-19333141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19333141 |
| http://purl.uniprot.org/uniprot/P33587 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19333141 |