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http://purl.uniprot.org/citations/19333934http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19333934http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To describe the classification, demographic and clinical features, and survival in anti-U3 RNP autoantibody-positive patients with systemic sclerosis (SSc).

Methods

Medical records of 108 anti-U3 RNP-positive and 2,471 anti-U3 RNP-negative SSc patients first evaluated during 1985-2003 were reviewed. Anti-U3 RNP antibody was detected by protein and RNA immunoprecipitation. Disease classification, demographic and clinical features, organ system involvement, and survival were compared between the 2 patient groups, by Student's t-test, chi-square analysis, and Mantel-Haenszel test.

Results

The anti-U3 RNP-positive group had a higher proportion of African American patients (27% versus 5%; P < 0.001) and male patients (29% versus 19%; P = 0.021), and was younger at the time of first physician diagnosis (mean age 42.8 years versus 47.4 years; P = 0.001). The 2 groups had similar proportions of patients with diffuse cutaneous involvement (47% and 45% in those with and those without anti-U3 RNP, respectively). However, among patients with diffuse cutaneous involvement, the mean maximum modified Rodnan skin score was significantly lower in the anti-U3 RNP group (22.3 versus 27.9; P < 0.001). Skeletal muscle involvement was more frequent in anti-U3 RNP-positive patients (25% versus 14%; P = 0.002), as was "intrinsic" pulmonary arterial hypertension (PAH) (31% versus 13%; P < 0.001). The frequency of gastrointestinal involvement, cardiac involvement, pulmonary fibrosis, and "renal crisis" did not differ significantly between the 2 groups. Survival was worse in the anti-U3 RNP-positive group (hazard ratio 1.38 [95% confidence interval 1.05-1.82]). PAH was the most common known cause of death in patients with anti-U3 RNP (30%, versus 10% in the anti-U3 RNP-negative group; P < 0.001).

Conclusion

The present findings demonstrate that the frequencies of African American race and male sex are greater among SSc patients with anti-U3 RNP antibody than those without, and the former group is younger at SSc diagnosis. Anti-U3 RNP-positive patients have more frequent skeletal muscle involvement and PAH, the latter being the most common cause of death."xsd:string
http://purl.uniprot.org/citations/19333934http://purl.org/dc/terms/identifier"doi:10.1002/art.24409"xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/author"Lucas M."xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/author"Fertig N."xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/author"Medsger T.A. Jr."xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/author"Aggarwal R."xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/author"Oddis C.V."xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/name"Arthritis Rheum"xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/pages"1112-1118"xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/title"Anti-U3 RNP autoantibodies in systemic sclerosis."xsd:string
http://purl.uniprot.org/citations/19333934http://purl.uniprot.org/core/volume"60"xsd:string
http://purl.uniprot.org/citations/19333934http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19333934
http://purl.uniprot.org/citations/19333934http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19333934
http://purl.uniprot.org/uniprot/#_O43818-mappedCitation-19333934http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19333934
http://purl.uniprot.org/uniprot/O43818http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19333934