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http://purl.uniprot.org/citations/19336370http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19336370http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Patent ductus arteriosus is a common morbidity associated with preterm birth. The incidence of patent ductus arteriosus increases with decreasing gestational age to approximately 70% in infants born at 25 weeks' gestation. Our major goal was to determine if genetic risk factors play a role in patent ductus arteriosus seen in preterm infants.

Methodology

We investigated whether single-nucleotide polymorphisms in genes that regulate smooth muscle contraction, xenobiotic detoxification, inflammation, and other processes are markers for persistent patency of ductus arteriosus. Initially, 377 single-nucleotide polymorphisms from 130 genes of interest were evaluated in DNA samples collected from 204 infants with a gestational age of <32 weeks. A family-based association test was performed on genotyping data to evaluate overtransmission of alleles.

Results

P values of <.01 were detected for genetic variations found in 7 genes. This prompted additional analysis with an additional set of 162 infants, focusing on the 7 markers with initial P values of <.01, and 1 genetic variant in the angiotensin II type I receptor previously shown to be related to patent ductus arteriosus. Of the initial positive signals, single-nucleotide polymorphisms in the transcription factor AP-2 beta and tumor necrosis factor receptor-associated factor 1 genes remained significant. Additional haplotype analysis revealed genetic variations in prostacyclin synthase to be associated with patent ductus arteriosus. An angiotensin II type I receptor polymorphism previously reported to be associated with patent ductus arteriosus after prophylactic indomethacin administration was not associated with the presence of a patent ductus arteriosus in our population.

Conclusions

Overall, our data support a role for genetic variations in transcription factor AP-2 beta, tumor necrosis factor receptor-associated factor 1, and prostacyclin synthase in the persistent patency of the ductus arteriosus seen in preterm infants."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.org/dc/terms/identifier"doi:10.1542/peds.2008-0313"xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Johnson K.J."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Zimmerman C.R."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Cooper M.E."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Murray J.C."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Dagle J.M."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Marazita M.L."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Caprau D."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Steffen K.M."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Kelsey K.J."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Lepp N.T."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Orr K.L."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/author"Schaa K.L."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/name"Pediatrics"xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/pages"1116-1123"xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/title"Determination of genetic predisposition to patent ductus arteriosus in preterm infants."xsd:string
http://purl.uniprot.org/citations/19336370http://purl.uniprot.org/core/volume"123"xsd:string
http://purl.uniprot.org/citations/19336370http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19336370
http://purl.uniprot.org/citations/19336370http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19336370
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-19336370http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19336370
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-19336370http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19336370
http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-19336370http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19336370
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