| http://purl.uniprot.org/citations/19339992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19339992 | http://www.w3.org/2000/01/rdf-schema#comment | "The unfolded protein response (UPR) is a specific cellular process that allows the cell to cope with the overload of unfolded/misfolded proteins in the endoplasmic reticulum (ER). ER stress is commonly associated with degenerative pathologies, but its role in disease progression is still a matter for debate. Here, we found that mutations in the ER-resident chaperone, neither inactivation nor afterpotential A (NinaA), lead to mild ER stress, protecting photoreceptor neurons from various death stimuli in adult Drosophila. In addition, Drosophila S2 cultured cells, when pre-exposed to mild ER stress, are protected from H(2)O(2), cycloheximide- or ultraviolet-induced cell death. We show that a specific ER-mediated signal promotes antioxidant defences and inhibits caspase-dependent cell death. We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.76"xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Dourlen P."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Steller H."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Chatelain G."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Mollereau B."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Ryoo H.D."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Gambis A."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Mendes C.S."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Dichtel-Danjoy M.L."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Fouillet A."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/author | "Levet C."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/pages | "1296-1307"xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/title | "ER stress protects from retinal degeneration."xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/19339992 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19339992 |
| http://purl.uniprot.org/citations/19339992 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19339992 |
| http://purl.uniprot.org/uniprot/P15425#attribution-BE98A570ACEC9DF470AC65E8EC529B37 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19339992 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI27-mappedCitation-19339992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19339992 |
| http://purl.uniprot.org/uniprot/#_P15425-mappedCitation-19339992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19339992 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHF0-mappedCitation-19339992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19339992 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7P1-mappedCitation-19339992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19339992 |