| http://purl.uniprot.org/citations/19342624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19342624 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has not been addressed. In this study, we generated a novel strain of BTLA-deficient mice and used three different models to characterize the function of BTLA in controlling T cell tolerance. In an oral tolerance model, BTLA-deficient mice were found resistant to the induction of T cell tolerance to an oral Ag. Moreover, compared with wild-type OT-II cells, BTLA(-/-) OT-II cells were less susceptible to tolerance induction by a high-dose OVA peptide administered i.v. Finally, BTLA(-/-) OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4(+) and CD8(+) T cells in vivo."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0803161"xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Lu S."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Kollias G."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Tian Q."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Nurieva R.I."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Graf D."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Chung Y."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Martin-Orozco N."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/author | "Alexiou M."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/pages | "4516-4520"xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/title | "Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction."xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19342624 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19342624 |
| http://purl.uniprot.org/citations/19342624 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19342624 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1A0-mappedCitation-19342624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19342624 |
| http://purl.uniprot.org/uniprot/#_E9QNY6-mappedCitation-19342624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19342624 |
| http://purl.uniprot.org/uniprot/#_Q32MV8-mappedCitation-19342624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19342624 |
| http://purl.uniprot.org/uniprot/#_Q32MV9-mappedCitation-19342624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19342624 |