| http://purl.uniprot.org/citations/19345193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19345193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19345193 | http://www.w3.org/2000/01/rdf-schema#comment | "Prions are proteins that convert between structurally and functionally distinct states, one or more of which is transmissible. In yeast, this ability allows them to act as non-Mendelian elements of phenotypic inheritance. To further our understanding of prion biology, we conducted a bioinformatic proteome-wide survey for prionogenic proteins in S. cerevisiae, followed by experimental investigations of 100 prion candidates. We found an unexpected amino acid bias in aggregation-prone candidates and discovered that 19 of these could also form prions. At least one of these prion proteins, Mot3, produces a bona fide prion in its natural context that increases population-level phenotypic heterogeneity. The self-perpetuating states of these proteins present a vast source of heritable phenotypic variation that increases the adaptability of yeast populations to diverse environments."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.02.044"xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.02.044"xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "Lindquist S."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "Lindquist S."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "Alberti S."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "Alberti S."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "Halfmann R."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "Halfmann R."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "Kapila A."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "Kapila A."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "King O."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/author | "King O."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/pages | "146-158"xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/pages | "146-158"xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/title | "A systematic survey identifies prions and illuminates sequence features of prionogenic proteins."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/title | "A systematic survey identifies prions and illuminates sequence features of prionogenic proteins."xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/19345193 | http://purl.uniprot.org/core/volume | "137"xsd:string |