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http://purl.uniprot.org/citations/19350523http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19350523http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To analyze the polymorphism and haplotypes of HLA-A, B, Cw, DRB1 and DQB1 loci in Chinese Han population.

Methods

A total of 186 unrelated healthy individuals from southern China were analyzed by sequence-based typing. Two-, three-, and five-locus haplotypes were estimated using the Expectation Maximization Algorithm. RESULTST: Twenty-eight alleles for the HLA-A locus, 49 HLA-B alleles, 24 HLA-C alleles, 29 HLA-DRB1 alleles and 20 HLA-DQB1 alleles were detected. The A*0207-B*4601(10.81%), A*3303-B*5801(6.14%), B*4601-DRB1*0901(6.22%), B*4001*-DRB1*0901(3.78%), DRB1*090-DQB1*0303 (12.16%) and DRB1*1202-DQB1*0301(8.38%), A*0207-B*4601-Cw*0102 (10.75%), A*3303-B*5801-Cw*0302 (5.14%), A*0207-B*4601-DR*0901(5.07%), A*3303-B*5801-DRB1*0301(2.96%), A*0207-B*4601-Cw*0102-DRB1*0901-DQB1*0303(4.87%) and A*1101-B*1301-Cw*0304-DRB1*1501-DQB1*0601(2.43%) were the most common haplotypes in the southern Chinese Han population.

Conclusion

The results have shown the characteristics of the five HLA loci haplotype distribution and provided more information in anthropology, disease association studies and transplantation."xsd:string
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http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/author"Deng Z.H."xsd:string
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/author"Cheng L.H."xsd:string
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/author"Zou H.Y."xsd:string
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/author"Gao S.Q."xsd:string
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/author"Jing S.Z."xsd:string
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/pages"228-232"xsd:string
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/title"[Analysis on haplotypes of five HLA loci in southern Chinese Han population by sequence-based typing]."xsd:string
http://purl.uniprot.org/citations/19350523http://purl.uniprot.org/core/volume"26"xsd:string
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