| http://purl.uniprot.org/citations/19350579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19350579 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell activation is regulated by binding of ligands on APC to corresponding receptors on T cells. In mice, we discovered that binding of DC-HIL on APC to syndecan-4 (SD-4) on activated T cells potently inhibits T-cell activation. In humans, we now show that DC-HIL also binds to SD-4 on activated T cells through recognition of its heparinase-sensitive saccharide moiety. DC-HIL blocks anti-CD3-induced T-cell responses, reducing secretion of pro-inflammatory cytokines and blocking entry into the S phase of the cell cycle. Binding of DC-HIL phosphorylates SD-4's intracellular tyrosine and serine residues. Anti-SD-4 Ab mimics the ability of DC-HIL to attenuate anti-CD3 response more potently than Ab directed against other inhibitory receptors (CTLA-4 or programmed cell death-1). Among leukocytes, DC-HIL is expressed highest by CD14(+) monocytes and this expression can be upregulated markedly by TGF-beta. Among APC, DC-HIL is expressed highest by epidermal Langerhans cells, an immature type of dendritic cells. Finally, the level of DC-HIL expression on CD14(+) monocytes correlates inversely with allostimulatory capacity, such that treatment with TGF-beta reduced this capacity, whereas knocking down the DC-HIL gene augmented it. Our findings indicate that the DC-HIL/SD-4 pathway can be manipulated to treat T-cell-driven disorders in humans."xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200838990"xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/author | "Chung J.S."xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/author | "Ariizumi K."xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/author | "Bonkobara M."xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/author | "Cruz P.D. Jr."xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/author | "Tomihari M."xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/pages | "965-974"xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/title | "The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses."xsd:string |
| http://purl.uniprot.org/citations/19350579 | http://purl.uniprot.org/core/volume | "39"xsd:string |
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