| http://purl.uniprot.org/citations/19351818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19351818 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid-induced gene G (RIG-G), a gene originally identified in all-trans retinoic acid-treated NB4 acute promyelocytic leukemia cells, is also induced by IFNalpha in various hematopoietic and solid tumor cells. Our previous work showed that RIG-G possessed a potent antiproliferative activity. However, the mechanism for the transcriptional regulation of RIG-G gene remains unknown. Here, we report that signal transducer and activator of transcription (STAT) 2 together with IFN regulatory factor (IRF)-9 can effectively drive the transcription of RIG-G gene by their functional interaction through a STAT1-independent manner, even without the tyrosine phosphorylation of STAT2. The complex IRF-9/STAT2 is both necessary and sufficient for RIG-G gene expression. In addition, IRF-1 is also able to induce RIG-G gene expression through an IRF-9/STAT2-dependent or IRF-9/STAT2-independent mechanism. Moreover, the induction of RIG-G by retinoic acid in NB4 cells resulted, to some extent, from an IFNalpha autocrine pathway, a finding that suggests a novel mechanism for the signal cross-talk between IFNalpha and retinoic acid. Taken together, our results provide for the first time the evidence of the biological significance of IRF-9/STAT2 complex, and furnish an alternative pathway modulating the expression of IFN-stimulated genes, contributing to the diversity of IFN signaling to mediate their multiple biological properties in normal and tumor cells."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-08-4922"xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Xiao S."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Zhang Z.L."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Chen S.J."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Jia P.M."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Pan X.R."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Tong J.H."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/author | "Lou Y.J."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/pages | "3673-3680"xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/title | "IRF-9/STAT2 functional interaction drives retinoic acid-induced gene G expression independently of STAT1."xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/19351818 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19351818 |
| http://purl.uniprot.org/citations/19351818 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19351818 |
| http://purl.uniprot.org/uniprot/#_P52630-mappedCitation-19351818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19351818 |
| http://purl.uniprot.org/uniprot/#_A0A7P0T7D6-mappedCitation-19351818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19351818 |
| http://purl.uniprot.org/uniprot/#_A0A510GDC6-mappedCitation-19351818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19351818 |
| http://purl.uniprot.org/uniprot/#_A5D905-mappedCitation-19351818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19351818 |
| http://purl.uniprot.org/uniprot/#_A0JLQ9-mappedCitation-19351818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19351818 |
| http://purl.uniprot.org/uniprot/#_D2KFR9-mappedCitation-19351818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19351818 |